Treating metritis has never
been easier

EXCEDE® (ceftiofur crystalline free acid) Sterile Suspension is approved for treatment of acute metritis in a two-dose regimen. To treat metritis, administer EXCEDE as a subcutaneous injection at the base of the ear and repeat this dose in the opposite ear approximately 72 hours following the initial dose.

Proven efficacy

Field trials1 demonstrate the effectiveness of a two-dose EXCEDE treatment for acute metritis. In one 15-dairy study, cows with acute metritis treated with two doses of EXCEDE — administered 72 hours apart at the base of opposite ears — experienced a significantly* greater cure rate than the untreated controls.

Download the complete study

Watch this video about EXCEDE, featuring Dr. Doug Hammon, to learn how EXCEDE can fit in your fresh cow management protocols.

Cure rate chart

Metritis stinks

Metritis is a uterine infection accompanied by inflammation involving all layers of the uterus that is most often diagnosed within the first 10 days after calving. Incidence rates for metritis range from 10 percent to 30 percent in dairy herds.


  • A foul-smelling, watery vaginal or uterine discharge
  • Fever of 103° F or higher
  • Uterus is thin-walled or contains gas
  • Depression, dehydration and lack of appetite

Risk factors:

  • Dystocia: 2.1 times greater risk2
  • Retained placenta: 6 times greater risk2
  • Ketosis: 1.5 times greater risk2
  • Twins: 10 times greater risk of dystocia, an indirect link to metritis2
  • Decreased dry matter intake: A drop in dry matter intake, as much as 30 percent or more, can occur with the addition of other stress factors.3

Metritis management brochure
Metritis risk factors article

Metritis costs add up

One case of metritis can cost more than $3504

Metritis costs

Important Safety Information: As with all drugs, the use of EXCEDE is contraindicated in animals with known allergy to ceftiofur or to the ß-lactam group (penicillins and cephalosporins) of antimicrobials. Though safe in cattle when properly administered, inadvertent intra-arterial injection is possible and fatal. EXCEDE has a pre-slaughter withdrawal time of 13 days following the last dose in cattle. Do not use in calves to be processed for veal.


  1. Data on file, Study Report No. 1133C-60-06-509, Zoetis Inc.
  2. Correa MT, Erb H, Scarlett J. Path analysis for seven postpartum disorders of Holstein cows. Journal of Dairy Science 1993;76(5):1305-1312.
  3. Overton MW, Boomer WG, Gorden PJ. Transition management checklist in Proceedings. 9th Annual Western Dairy Management Conference
  4. Overton MW, Fetrow J. Economics of postpartum uterine health in Proceedings. 2008 Dairy Cattle Reproduction Council Convention. 2008;24-29.
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