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Be Sure You Have An Effective Vaccine

Demonstrated Protection of FluSure® Pandemic in Pigs Challenged with PH1N1

Challenged with pH1N1, pigs vaccinated with FluSure® Pandemic helps provide optimum immunity against a homologous (same) strain of swine influenza circulating in North American pigs.1,2

Demonstrated Protection of FluSure XP®

Zoetis is committed to ensuring FluSure XP® covers the most prevalent IAV-S strains circulating in swine production.3

Protection was demonstrated by reduction of lung lesions, rectal temperature, nasal shedding and viral titer in bronchoalveolar lavage fluid at necropsy.4 This means the most demonstrated, relevant cross-protection against the following strains:3,4,5

  1. Delta-1 H1N2
  2. Gamma H1N1
  3. Clusters IV-A and IV-B of the H3N2 subtype

When pigs vaccinated with FluSure XP were challenged with a virulent H3N2 Cluster IV-A strain, the vaccine had:4

Lung lesions reduction
71% reduction in lung lesions
Nasal shedding and BAL fluids reduction
85% reduction in nasal shedding and 100% reduction in BAL fluids

Nasal virus titers
Lower mean nasal virus titers
HI antibody cross-reactivity
Demonstrated HI antibody titer cross-reactivity

  1. Lee JH, Gramer MR, Joo HS. Efficacy of swine influenza A virus vaccines against an H3N2 virus variant. Can J Vet Res. 2007;71(3):207-212.
  2. Lager KM, Vincent AL, Zanella J et al. Update on 2009 Pandemic H1N1 Influenza Virus Infections of Swine, in Proceedings. 18th Annu Iowa State Univ Swine Dis Conf 2010;128-131.
  3. Veterinary Services, Animal and Plant Health Inspection Services, US Department of Agriculture. Influenza A Virus in Swine Surveillance: Fiscal Year 2015 Quarterly Report; Surveillance Summary for Fourth Quarter FY 2015. Published February 2016. https://www.aphis.usdagov/animal_health/animal_dis_spec/swine/downloads/fy2015quarter4swinereport.pdf
  4. Data on file, Study Report No. B820R-US-14-436, Zoetis Inc.
  5. FluSure XP® [package]. Kalamazoo, MI: Zoetis Inc. 2016.