Challenge studies are considered the gold standard of determining vaccine effectiveness. The following are challenge studies and supporting research performed to evaluate the effectiveness of FluSure XP® in pigs challenged with field strains.
Delta 1 H1N2
Challenged with Delta 1 H1N2, pigs vaccinated with updated FluSure XP showed:1
- Reduced clinical signs of flu
- Reduced viral shedding
- Reduced lung lesions
- Increased antibody titers against Delta 1 H1N2
View the FluSure XP: Delta 1 H1N2 Challenge Study Technical Update for complete trial design, results and discussion.
A university study showed that pigs vaccinated with FluSure XP were protected against Alpha H1N1, a strain that is antigenically different from the strain contained in the vaccine.2
A university study showed that pigs vaccinated with FluSure XP were protected against Beta H1N1, a strain that is antigenically different from the strain contained in the vaccine.3,4
Studies showed a reduction in viral shedding when pigs vaccinated with FluSure XP were challenged with Gamma H1N1.5
Delta 2 H1N1
When pigs vaccinated with FluSure XP were challenged with Delta 2 H1N1, the vaccine:
- Reduced lung lesions and viral shedding6
- Simulated circulating HI antibody titers6
Cluster IV H3N2
When pigs vaccinated with FluSure XP were challenged with Cluster IV H3N2, the vaccine:
- Reduced lung lesions and viral shedding7
- Simulated circulating HI antibody titers7
Duration of immunity
A duration of immunity of at least 10 weeks, as demonstrated by a reduction in lung lesions, has been demonstrated against respiratory disease caused by SIV H3N2.8
View the following Technical Bulletins for more information.
1. Data on file, Study Report No. 3127R-60-10-917, Zoetis Inc.
2. Kitikoon P, Nilubol D, Vincent A, Yu S, Erickson B, Janke B, Hoover T, Sornsen S, Thacker E. Immune response and effect of maternal antibody interference on vaccination with a bivalent swine influenza vaccine. Proceedings of the 18th IPVS Congress. Hamburg, Germany. 2004;1:386.
3. Gramer M. Epidemiology of swine influenza and implications of reassortment. 2004 Allen D. Leman Swine Conference. 2004; p69-73.
4. Rapp-Gabrielson VJ, Wicklund E, Ficken M. Efficacy of FluSure® against challenge with heterologous reassortant swine influenza H1N1 viruses. 2005 Allen D. Leman Conference
5. Data on file, Study Report No, 2124C-60-00301-060, Zoetis Inc.
6. Data on file, Study Report No. 3121R-60-07-538, Zoetis Inc.
7. Data on file, Study Report No. 3121R-60-07-529, Zoetis Inc.
8. Data on file, Study Report No. 2124H-60-02-019, Zoetis Inc.
- Belgium (French)
- Belgium (Dutch)
- Costa Rica
- Czech Republic
- New Zealand
- South Africa
- South Korea
- United Kingdom
- United States