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The Danger of the Evolving PCV2 virus

There are four known PCV2 genotypes present in U.S. swine herds: PCV2a, PCV2b, PCV2d and occasionally PCV2e, with prevalence shifting in the past several years to PCV2b1 and now PCV2d.2 PCV2d was originally referred to as mutant PCV2b,3 and sequence analysis confirms that it is more similar to PCV2b than to PCV2a.4 Until now, all commercial PCV2 vaccines contained a single PCV2 genotype, meaning you could have less coverage against more prevalent or evolving strains in circulation.5-8

Summary of PCV2 genotype sequences at the Iowa State University Veterinary Diagnostic Laboratory from 2013 to 2017

PCV2 FACTS

  • PCV2 has the highest mutation rate reported for a single-stranded DNA virus.9
  • The genetic gap between PCV2 vaccines and viruses is increasing.10,11
  • PCV2 is one of the most economically important diseases in the swine industry.12

A dangerous combination: M. hyo and PCV2

When clinical pneumonia is decreasing herd productivity, you might start looking for a single culprit, such as PCV2 or M. hyo. But complex respiratory challenges are rarely caused by just one pathogen. 

Viral and bacterial infectious agents can open the door for one another when a pig’s immune system is compromised. An M. hyo infection can last 15 to 28 weeks after initial exposure.13-16

Fostera® Gold PCV MH can help you protect your operation from PCV2 and M. hyo.

Broadest PCV2 antigenic protection
 
Summary of PCV2 genotype sequences at the Iowa State University Veterinary Diagnostic Laboratory from 2013 to 2017

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