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TRIAMULOX

Triamulox

Triamulox Logo

Triamulox Liquid Concentrate is a formulation of tiamulin hydrogen fumarate for the treatment of two important infectious diseases of pigs: swine dysentery and swine pneumonia. The “high potency, low resistance” properties, given over five days without age restrictions in drinking water, make Triamulox a great choice for quick, effective whole-herd treatment using a convenient liquid concentrate formulation.

As with all disease treatments, we recommend working with your veterinarian to diagnose the condition affecting your pigs and the best treatment option for them.

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    • The same proven efficacy as Denagard® LC
      Approved bioequivalent to Denagard® LC for swine dysentery and swine pneumonia1 

    • Convenient dosing via daily drinking water
      A liquid concentrate formulation of tiamulin hydrogen fumarate to effectively treat swine dysentery, swine pneumonia, or both2

    • The assurance of high potency, low resistance tiamulin hydrogen fumarate
      Tiamulin hydrogen fumarate is widely considered to be the most effective antimicrobial against swine dysentery caused by Brachyspira hyodysenteriae3,4

    • Quick, effective, whole-herd treatment
      Five-day dosing, no age restrictions2,3 

    References: 

    1. US Food and Drug Administration. Freedom of Information Summary. Original abbreviated new animal drug application. ANADA 200-512 TRIAMULOX. Last updated November 7, 2014. Accessed June 23, 2016. (Download PDF)

    2. Triamulox [package insert]. Kalamazoo, MI: Zoetis Inc; 2016.

    3. Wilberts BL, Arruda PH, Warneke HL, Erlandson KR, Hammer JM, Burrough ER. Cessation of clinical disease and spirochete shedding after tiamulin treatment in pigs experimentally infected with “Brachyspira hampsonii”. Res Vet Sci. 2014;97(2):342–348.

    4. Krasucka D, Mitura A, Cybulski W, et al. Tiamulin hydrogen fumarate - veterinary uses and HPLC method of determination in premixes and medicated feeding stuffs. Acta Pol Pharm. 2010;67(6):682–685.

  • The concentration of Triamulox in the drinking water must be adjusted to compensate for variation in water consumption due to weight or size of the pig, environmental temperature, and other factors. 

    It is important that pigs receive the proper dose, 3.5 mg tiamulin hydrogen fumarate per pound for swine dysentery or 10.5 mg tiamulin hydrogen fumarate per pound for swine pneumonia, each day for five consecutive days.

    Prepare fresh medicated drinking water every day for the five-day treatment period.

    Water medicated with Triamulox should be the only source of drinking water during the treatment period.

    Directions for using Triamulox Liquid Concentrate in medicated proportioners:
    One quart of Triamulox mixed with water to make four gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 512 gallons of drinking water for treatment of swine dysentery. Three quarts of Triamulox mixed with water to make four gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 681 mg tiamulin hydrogen fumarate per gallon to a total of 512 gallons of drinking water for treatment of swine pneumonia.

    Directions for preparing Triamulox Liquid Concentrate medicated solutions:
    Determine the amount of Triamulox needed to medicate the desired volume of drinking water at the proper concentration. Carefully measure out this amount, add it to the water, and stir to thoroughly mix.

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     Triamulox Liquid Concentrate

    Net tiamulin hydrogen fumarate content per quart bottle:

    116,400 mg

    Diseases to be treated:

    Swine dysentery

    Swine pneumonia

    Daily tiamulin hydrogen fumarate required per pound of pig body weight:

    3.5 mg

    10.5 mg

    Required treatment duration:

    5 days

    Pig body weight this bottle will treat for ONE day:

    33,257 lb

    11,086 lb

    Number of pigs this bottle will treat for ONE day:

    Pig body weight (lb) 

    20 

    45 

    75 

    125 

    180 

     

     

    1,663

    739

    443

    266

    185

     

     

     554

    246

    148

    88

    62

    Suggested final dilution of:

    1 bottle 

    3 bottles 

    1/2 pint (8 oz) 

    1 1/2 pints (24 oz) 

     

    512 gal

    128 gal

     

    – 

    512 gal

    43 gal

    128 gal

    Tiamulin hydrogen fumarate concentration per gallon at suggested final dilution*

    227 mg
    (60 ppm)

    681 mg
    (180 ppm)

    Mixing a 4-gallon stock solution

    1 quart Triamulox

    3 quarts Triamulox

    *Note: Increase or decrease dilution rate as required to obtain proper daily drug dose. 

    While Triamulox is not a prescription product, as with all antibiotics, we recommend producers work with their veterinarian to properly diagnose the disease being treated and the most effective treatment for their pigs.

    Please see Product Label for full dosage information.

IMPORTANT SAFETY INFORMATION

Contraindications: Swine being treated with Triamulox should not have access to feeds containing polyether ionophores (eg, monensin, lasalocid, narasin, salinomycin and semduramicin) as adverse reactions may occur.

Warning: Keep out of reach of children. Avoid contact with skin. Direct contact with skin or mucous membranes may cause irritation.

Residue Warning: Withdraw medicated water three days before slaughter after treatment at 3.5 mg per pound and seven days before slaughter following treatment at 10.5 mg per pound body weight.

Caution: For use in drinking water of swine only. Prepare fresh medicated water daily. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined. For animal use only—not for use in humans.

Adverse Reactions: Overdoses of Triamulox have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. If signs of toxicity occur, discontinue use of medicated water and replace with clean, fresh water.

In rare cases, redness of the skin primarily over the ham and underline has been observed during medication. If these signs appear, discontinue use of this drug. Provide ample clean drinking water. Thoroughly rinse (hose down) the housing to remove urine and feces from animal contact surfaces or move the animals to clean pens. If the condition persists, consult your veterinarian.

Studies to evaluate the safety of the water soluble form of tiamulin in breeding swine have not been done.

Talk with your veterinarian about Triamulox.

Reference:

  1. US Food and Drug Administration. Freedom of Information Summary. Original abbreviated new animal drug application. ANADA 200512 TRIAMULOX.
    Last updated November 7, 2014. Accessed June 23, 2016. (Download PDF)

Denagard® LC is a registered trademark of Eli Lilly and Company.