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More protection. More productivity.

Every hen that is protected has the potential to produce more. In commercial layer production, Escherichia coli (E. coli) can be everywhere and the predisposing environmental factors are impossible to eliminate. Each factor can spark colibacillosis and respiratory distress, increase mortality and reduce flock performance. As the industry migrates toward cage-free production in the years ahead, bacterial challenges will likely follow.

Poulvac® E. coli is the only available modified-live E. coli vaccine that is safe for birds.1 Recommended for mass administration to healthy chickens 1 day of age or older, it helps provide broad-spectrum protection against E. coli bacteria,2 and has shown to reduce mortality and potential egg losses.3,4

Demonstrated results

In a study measuring protection in specific-pathogen-free (SPF) chickens, birds were vaccinated at 1 day after hatch, given a 14-week booster, then challenged at week 20 with E. coli serotype O78 isolate.2

Poulvac E. coli:

  • Reduced pericarditis lesions from 68% to 33%
  • Reduced airsacculitis from 80% to 38%
  • Reduced mortality from 60% to 12%


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P-value: Less than or equal to 0.05.

The power of one more egg

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According to one of the industry’s leading layer veterinarians, leaving five eggs per bird on the table can cost producers at least $35,000 in profit when market prices are high. Layer vaccination programs are almost always cost-effective in disease challenged areas under these circumstances.5

Poulvac E. coli can help deliver a strong return on investment for egg producers. Saving even just one egg per hen housed reduces mortality and maintains production past peak. The table below demonstrates the economic benefits of a $2,600 investment for two doses of Poulvac E. coli vaccination in a 100,000-hen operation.

Potential returns on Poulvac® E. coli vaccination: lower-end and higher-end mortality reduction scenarios

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Based on $2,600 investment for vaccinating 100,000 layer chick flock with two doses of Poulvac E. coli

A Calculations assume the following industry standards, as per a 2015 industry analysis:

  • 100,000 chicks placed, with standard 5% mortality during rearing
  • Chick cost: $0.77
  • Overhead: $1.08
  • Feed cost/ton: $229.19
  • Genetic standard: 340 eggs per hen housed
  • Actual production: 327 eggs per hen housed
  • Production with vaccination: 328 eggs per hen housed

B Egg prices based on three-year combined regional large egg prices6

What Zoetis can do for you

Zoetis is committed to providing insightful veterinary service. We work to better understand your company’s flock health challenges and to offer insights and disease management strategies designed to help your operation thrive.

We help built Poulvac E. coli vaccination protocols that make sense for your business. We audit vaccine and crew administration performance to maximize efficiency. And the Poulvac portfolio from Zoetis includes a number of additional vaccines for diseases affecting layer operations, including Salmonella and Infectious Bronchitis.



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