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When it comes to Salmonella management, taking a prevention-oriented approach is helping reduce contamination in chickens, resulting in more valued chicken and eggs.

Poulvac® ST from Zoetis is a modified-live vaccine that helps poultry companies reduce their overall Salmonella load at critical points in poultry supply chains. It provides broad-spectrum protection against several Salmonella serotypes within groups B, C and D by reducing Salmonella colonization of internal organs and ceca.1-5

Proven advantages under commercial broiler conditions

Poulvac ST has demonstrated impact where it matters most — in the processing plant. In a recent broiler field study comparing millions of birds over a 14-week span, Poulvac ST helped provide the following advantages relative to unvaccinated controls: 6

  • 2.5 times reduction in the percentage of Salmonella-positive broiler rinsates at rehang (16.2% vs. 6.4%).
  • 3 times reduction of the recovery of Group B and Group C serotypes.
  • Vaccinated birds also held a feed conversion advantage.

Protection without detection

While Poulvac ST stimulates immunity that reduces Salmonella colonization, the vaccine’s construction helps ensure it will not be detected by U.S. Department of Agriculture inspectors. Therefore, the vaccine's use will not lead to false positives in the processing plant.

This is because Poulvac ST contains a gene-deleted aroA mutant that causes the vaccine to stop replicating once aromatic amino acids are no longer available. So, while the vaccine strain is recoverable at up to two weeks post-vaccination7,8 the vaccine isolate will not persist in the bird, on the bird or in the environment.

Part of an integrated Salmonella management approach

Poulvac ST is part of a comprehensive offering of preharvest and post-harvest interventions from Zoetis, all backed by decades of hatchery, veterinary and processing expertise.

Reducing Salmonella colonization in commercial layers

Poulvac ST helps stimulate cell-mediated immunity, making it an effective tool for priming pullet immune systems to maximize the opportunity for inactivated S. enteritidis vaccines to be successful. Poulvac ST has demonstrated a 50% reduction of S. kentucky, S. enteritidis, S. heidelberg, S. typhimurium and S. hadar incidence, as measured by positive samples collected from internal organs.1-5

Poulvac ST® is part of the Poulvac Salmonella portfolio, which also includes Poulvac SE and Poulvac SE-ND-IB, to give egg producers a comprehensive set of tools to help prevent Salmonella colonization. These vaccines are supported by account managers and veterinarians dedicated to commercial layer production, providing on-farm services for promoting proper vaccination administration and measuring vaccine performance.

Contact your Zoetis representative to review and optimize your integrated Salmonella management program.

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  • Poulvac® ST is a live vaccine composed of a modified-live Salmonella typhimurium, aiding in the reduction of Salmonella enteritidis, Salmonella heidelberg or Salmonella typhimurium colonization of the internal organs, including the intestines and ceca.

  • Poulvac ST is supplied in two package sizes:

    • Pullet presentation: 10 vials x 5,000 doses
    • Hatchery presentation: 10 vials x 20,000 doses
  • Spray administration:

    1. Remove seal and stopper. Half fill vial with cool, distilled water. Replace stopper and shake until dissolved.
    2. Pour rehydrated vaccine into a clean container and add cool, distilled water to dilute the vaccine as indicated for your specific coarse spray vaccination machine. For example, use a total of 500 mL of water per 5,000 doses of vaccine. Mix thoroughly.
    3. Administer at a rate of one dose of prepared vaccine per bird.

    Drinking water administration:

    1. Discontinue use of medications or sanitizing agents (such as chlorine) in the drinking water 24 hours before vaccinating. Do not resume use for 24 hours following vaccination.
    2. Provide enough waterers so two-thirds of the birds may drink at one time. Scrub waterers with fresh, clean, nonchlorinated water and drain dry. Do not give vaccine water through medication tanks.
    3. Turn off automatic waterers two to four hours before vaccinating so that the only available water is the vaccine water. Do not deprive birds of water in extremely hot weather.
    4. Remove seal and stopper. Half fill with clean, cool nonchlorinated water. Replace stopper and shake until dissolved.
    5. Use a clean container two-thirds filled with cool, clean, nonchlorinated water. Add dried milk at a rate of 1 ounce per 2.5 gallons.
    6. Add the rehydrated vaccine. Stir thoroughly and add water to make final mixture at a rate of 5,000 doses per 12.5 gallons.
    7. Give one dose of vaccine per bird, distributing the final volume of vaccine water evenly among the clean waterers. Do not place the waterers in direct sunlight.
    8. Resume regular water administration only after all the vaccine water has been consumed.
    • Do not store over 8°C (46°F).
    • Vaccinate only healthy birds.
    • If possible, vaccinate all susceptible birds on the premises at the same time.
    • Use entire contents when vial is first opened.
    • Inactivate unused contents before disposal.
    • Not for human use.
    • Withholding period: 21 days before slaughter.
  • 1 Data on file, Study Report B-393-98-A6.R, Zoetis Inc

    2 Data on file, Study Report B-393-98-A8.R, Zoetis Inc

    3 Data on file, Study Report B-393-99-A2.R, Zoetis Inc

    4 Data on file, Study Report B-393-00-AI.R, Zoetis Inc

    5 Data on file, Study Report B-393-01-AI.R, Zoetis Inc

    6 Data on file, Study Report No. 04-16-7ADMJ, Zoetis Inc

    7 Data on file, Study Report TIA 22492, Zoetis Inc

    8 Study on file, Study Report TIA 22485, Zoetis Inc




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